NanoDendrix™
NanoDendrix™ technology is based on monodisperse glycogen nanoparticles extracted from sweet corn. These nanoparticles are:
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safe (certified GRAS)
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biodegradable
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hydrophilic
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temperature and pressure stable
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easily chemically modifiable
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Manufactured at scale
Both of Glysantis' therapeutic candidates utilize the new biology or chemistry unlocked by NanoDendrix™ particles. See scientific publications below.
The technology was originally discovered at the University of Guelph and commercialized by Mirexus Biotechnologies Inc., our parent company.
Click here for more information on the physical and chemical properties of NanoDendrix™ glycogen nanoparticles.
Composed of glucose monomers
Highly branched dendrimeric structure
Diameter: ~45 nm
MW: ~5 MDa (5,000 KDa)
A molecular dynamics model of a single phytoglycogen molecule (DeHaan, H., et al, 2018)
Publications
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J.R. Dutcher, M. Grossutti, J. Atkinson, B. Baylis, H. Shamana, E. Bergmann, J. Nickels and J. Katsaras. Phytoglycogen Nanoparticles: Exciting Science and Promising Technologies From Nature, Phys. Canada 73, 91-94 (2017).
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M. Grossutti and J.R. Dutcher. Correlation Between Chain Architecture and Hydration Water Structure in Polysaccharides, Biomacromolecules 17, 1198-1204 (2016).
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J.D. Nickels, J. Atkinson, E. Papp-Szabo, C. Stanley, S.O. Diallo, S. Perticaroli, B. Baylis, P. Mahon, G. Ehlers, J. Katsaras and J.R. Dutcher. Structure and Hydration of Highly-Branched, Monodisperse Phytoglycogen Nanoparticles, Biomacromolecules 17, 735-743 (2016).