©2020 Glysantis

Innate Immune Boosting

The innate immune system is the body's first line of defense against invading pathogens and cancerous cells. A viral by-product called double-stranded RNA (dsRNA) is recognized by innate immune receptors in most cells, which kicks off a signaling cascade resulting in the production of important immune factors called cytokines and chemokines, which attract immune cells to the pathogens or, in the case of cancer, the tumor cells. 

Researchers and companies have previously attempted to utilize a synthetic analog of dsRNA called polyinosinic:polycytidylic acid or poly(I:C) as a therapeutic agent, but have failed due to various limitations of poly(I:C).

 

When we attach poly(I:C) to NanoDendrix particles™ [NDX-poly(I:C)] some very interesting and unexpected things happen:

  • Poly(I:C) molecules, which are heterogeneous in composition, take on the nanoparticle's configuration and assume a homogenous composition. This is important from safety and formulation perspectives. 

  • Attaching poly(I:C) to the NanoDendrix™ particles increases the functional potency of poly(I:C) 21-fold over free poly(I:C)

  • In some cancer cells and immune cells, NDX-poly(I:C) induces the expression of cytokines (IFNb, IL6), interferon-stimulated genes (ISG15, PDL-1) and chemokines (CXCL10) at concentrations where poly(I:C) alone is ineffective. 

Click here to download a non-confidential slide deck with more information about Glysantis' technology and pipeline.